Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation for many medical conditions. It is the active ingredient in the over the counter medication Aleve. Take valacyclovir exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label. You can take these drugs safely. Ibuprofen is a non-steroidal anti-inflammatory pain medicine. Valtrex is an antiviral. Remember that ibuprofen is harsh on your stomach. Frequently asked questions about Can i take valtrex and aleve. These two drugs should be safe to take together. To be sure thatthis is a good combination of medications for you, check with yourdoctor. Take Valtrex exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label. I took Valtrex 2x a day for about 15 days and then my dr told me to take it 1x a day.I do feel better, but I still do have some itching and pain -- but Aleve seems to relieve the pain. Do not take any medication that contains acyclovir while taking Valtrex. It can lead potentially dangerous levels of acyclovir in the blood. It can lead potentially dangerous levels of acyclovir in the blood. If you have any abdominal pain, stop the ibuprophen immediately. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Wright on valtrex and ibuprofen: The only problen i see is that you are on zantac (ranitidine) presumably for gastritis/gerd. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Abe on valtrex and advil: Yes IF you are not pregnant, have not had any past problems with Amoxibron or medicines similar to Penicillin and no past problems with Ibuprofen and/or decongestant medicines. Don't use Advil (ibuprofen) Cold & Sinus if you have high blood. Summary. Drug interactions are reported among people who take Valtrex and Aleve together. This study is created by eHealthMe based on reports of 209 people who take Valtrex and Aleve from FDA, and is updated regularly.